Our R&D area is as follows;
Drug delivery, Cosmetic ingredients delivery, Gene Delivery, Cancer Targeting, imaging and therapy, Tissue engineering.
Our current focus is on the development of polymers (nano-capsule) as a platform to deliver drugs and cosmetic ingredients.
“Micropatterned hydrogel surface with high-aspect-ratio features for cell guidance and tissue growth,” Yuhang Hu, Jin-Oh You, and Joanna Aizenberg, ACS Applied Materials & Interfaces, 2016, 8(34) 21939-21945.
“siRNA delivery impedes the temporal expression of cytokine-activated VCAM1 on endothelial cells,” Theodore T. Ho, Jin-Oh You, and Debra T. Auguste, Annals of Biomedical Engineering, 2016, 44(4) 895-902.
“pH-Responsive Scaffolds Generate a Pro-Healing Response,” Jin-Oh You, Marjan Rafat, Dariela Almeda, Natalia Maldonado, Peng Guo, Christoph S. Nabzdyk, Maggie Chun, Frank W. LoGerfo, John W. Hutchinson, Leena Pradhan-Nabzdyk, and Debra T. Auguste, Biomaterials, 2015, 57, 22-32.
“Development of a composite electrospun polyethylene terephthalate-polyglycolic acid material: potential use as a drug-eluting vascular graft,” Christoph S. Nabzdyk, Maggie C. Chun, Saif G. Pathan, David W. Nelson, Jin-Oh You, Matthew D. Phaneuf, Frank W. LoGerfo, and Leena K. Pradhan-Nabzdyk, Journal of Nanomaterials, 2015, 2915 1.
“Inhibiting metastatic breast cancer cell migration via the synergy of targeted, pH-triggered siRNA delivery and chemokine axis blockade,” Peng Guo, Jin-Oh You, Jiang Yang, Di Jia, Marsha A. Moses, and Debra T. Auguste, Molecular Pharmaceutics, 2014, 11(3) 755-765.
“Gene silencing in human aortic smooth muscle cells induced by PEI–siRNA complexes released from dip-coated electrospun poly(ethylene terephthalate) grafts,” Christoph S. Nabzdyk, Maggie C. Chun, Hunter S. Oliver-Allen, Saif G. Pathan, Matthew D. Phaneuf, Jin-Oh You, Leena K. Pradhan-Nabzdyk, and Frank W. LoGerfo, Biomaterials, 2014, 35(9) 3071-3079.
“A drug-delivery vehicle combining the targeting and thermal ablation of HER2+ breast-cancer cells with triggered drug release,” Jin-Oh You, Peng Guo, and Debra T. Auguste, Angewandte Chemie-International Edition, 2013, 52(15) 4141-4146.
“Using breast cancer cell CXCR4 surface expression to predict liposome binding and cytotoxicity,” Peng Guo, Jin-Oh You, Jiang Yang, Marsha A. Moses, and Debra T. Auguste, Biomaterials, 2012, 33(32) 8104-8110.
“Dual functionalized PVA hydrogels that adhere endothelial cells synergistically,” Marjan Rafat, Lisa Rotenstein, Jin-Oh You, and Debra T. Auguste, Biomaterials, 2012, 33(15) 3880-3886.
“Indentation: A simple, nondestructive method for characterizing the mechanical and transport properties of pH-sensitive hydrogels,” Yuhang Hu, Jin-Oh You, Debra T. Auguste, Zhigang Suo, and Joost J. Vlassak, Journal of Materials Research, 2012, 27(01) 152-160.
“Cross-linked, heterogeneous colloidosomes exhibit pH-induced morphogenesis,” Jin-Oh You, Marjan Rafat, and Debra T. Auguste, Langmuir, 2011, 27(18) 11282-11286.
“Nanoengineering the heart: Conductive scaffolds enhance connexin 43 expression,” Jin-Oh You, Marjan Rafat, George J. C. Ye, and Debra T. Auguste, Nano Letters, 2011, 11(9) 3643-3648.
“Bioresponsive matrices in drug delivery,” Jin-Oh You, Dariela Almeda, George J. C. Ye, and Debra T. Auguste, Journal of Biological Engineering, 2010, 4(15) 1-12.
“The effect of swelling and cationic character on gene transfection by pH-sensitive nanocarriers,” Jin-Oh You and Debra T. Auguste, Biomaterials, 2010, 31(26) 6859-6866.
“Conductive, physiologically responsive hydrogels,” Jin-Oh You and Debra T. Auguste, Langmuir, 2010, 26(7) 4607-4612.
“Nanocarrier cross-linking density and pH sensitivity regulate intracellular gene transfer,” Jin-Oh You and Debra T. Auguste, Nano Letters, 2009, 9(12) 4467-4473.
“Feedback-regulated paclitaxel delivery based on poly(N,N-dimethylaminoethyl methacrylate-co-2-hydroxyethyl methacrylate) nanoparticles,” Jin-Oh You and Debra T. Auguste, Biomaterials, 2008, 29(12) 1950-1957.