We Are Biotechnology Venture
Whose mission is on the development and commercialization of
Drug Delivery Systems through the interface between biomedical and chemical science.
Our current focus is on the development of Polymers as a platform to deliver drugs and cosmetic ingredients
Founders
Sanghoon Lee
Prior to Bilico, Sanghoon served successfully as head of business planning for a bio venture company. Before that Sanghoon was responsible for M&A and business development for CKD Holdings, major Korean pharmaceutical company. Prior to CKD holdings, he was leader of business development for EO Technics, a publicly listed manufacturing company. Earlier in his career, he worked for KPMG consulting and Mizuho Financial group in New York for business development and finance.
Sanghoon holds MBA from Seoul national university, Master’s degree in accountancy from Baruch college and bachelor’s degree in economics from Sungkyunkwan university. Also he is a member of AICPA(American institute of CPAs)
Jin-Oh You, Ph.D.
Dr. You received his Ph.D. from the University of Southern California, Los Angeles, USA, and was a postdoctoral fellow at the lab of Prof. Robert Langer at MIT and Harvard University. And, he worked for Harvard University as a research associate in the both Biomedical Engineering and Physics Departments. His research focuses on the biomedical applications of smart biomaterials such as drug/gene delivery, tissue engineering, cosmetics, stem cells, pharmaceuticals, etc.
Dr. You conducted various interdisciplinary research projects on polymer engineering, chemistry, biology, and medicine with NIH, NSF, DARPA, American Heart Association, and American Diabetes Research Foundation. His research works have highlighted in science magazines such as Nature Nanotechnology, Materials Today, MRS Bulletin, Nano Today , etc.
R&D
Our R&D area is as follows;
Drug delivery, Cosmetic ingredients delivery, Gene Delivery, Cancer Targeting, imaging and therapy, Tissue engineering.
Our current focus is on the development of polymers (nano-capsule) as a platform to deliver drugs and cosmetic ingredients.
PUBLICATION
“Micropatterned hydrogel surface with high-aspect-ratio features for cell guidance and tissue growth,” Yuhang Hu, Jin-Oh You, and Joanna Aizenberg, ACS Applied Materials & Interfaces, 2016, 8(34) 21939-21945.
“siRNA delivery impedes the temporal expression of cytokine-activated VCAM1 on endothelial cells,” Theodore T. Ho, Jin-Oh You, and Debra T. Auguste, Annals of Biomedical Engineering, 2016, 44(4) 895-902.
“pH-Responsive Scaffolds Generate a Pro-Healing Response,” Jin-Oh You, Marjan Rafat, Dariela Almeda, Natalia Maldonado, Peng Guo, Christoph S. Nabzdyk, Maggie Chun, Frank W. LoGerfo, John W. Hutchinson, Leena Pradhan-Nabzdyk, and Debra T. Auguste, Biomaterials, 2015, 57, 22-32.
“Development of a composite electrospun polyethylene terephthalate-polyglycolic acid material: potential use as a drug-eluting vascular graft,” Christoph S. Nabzdyk, Maggie C. Chun, Saif G. Pathan, David W. Nelson, Jin-Oh You, Matthew D. Phaneuf, Frank W. LoGerfo, and Leena K. Pradhan-Nabzdyk, Journal of Nanomaterials, 2015, 2915 1.
“Inhibiting metastatic breast cancer cell migration via the synergy of targeted, pH-triggered siRNA delivery and chemokine axis blockade,” Peng Guo, Jin-Oh You, Jiang Yang, Di Jia, Marsha A. Moses, and Debra T. Auguste, Molecular Pharmaceutics, 2014, 11(3) 755-765.
“Gene silencing in human aortic smooth muscle cells induced by PEI–siRNA complexes released from dip-coated electrospun poly(ethylene terephthalate) grafts,” Christoph S. Nabzdyk, Maggie C. Chun, Hunter S. Oliver-Allen, Saif G. Pathan, Matthew D. Phaneuf, Jin-Oh You, Leena K. Pradhan-Nabzdyk, and Frank W. LoGerfo, Biomaterials, 2014, 35(9) 3071-3079.
“A drug-delivery vehicle combining the targeting and thermal ablation of HER2+ breast-cancer cells with triggered drug release,” Jin-Oh You, Peng Guo, and Debra T. Auguste, Angewandte Chemie-International Edition, 2013, 52(15) 4141-4146.
“Using breast cancer cell CXCR4 surface expression to predict liposome binding and cytotoxicity,” Peng Guo, Jin-Oh You, Jiang Yang, Marsha A. Moses, and Debra T. Auguste, Biomaterials, 2012, 33(32) 8104-8110.
“Dual functionalized PVA hydrogels that adhere endothelial cells synergistically,” Marjan Rafat, Lisa Rotenstein, Jin-Oh You, and Debra T. Auguste, Biomaterials, 2012, 33(15) 3880-3886.
“Indentation: A simple, nondestructive method for characterizing the mechanical and transport properties of pH-sensitive hydrogels,” Yuhang Hu, Jin-Oh You, Debra T. Auguste, Zhigang Suo, and Joost J. Vlassak, Journal of Materials Research, 2012, 27(01) 152-160.
“Cross-linked, heterogeneous colloidosomes exhibit pH-induced morphogenesis,” Jin-Oh You, Marjan Rafat, and Debra T. Auguste, Langmuir, 2011, 27(18) 11282-11286.
“Nanoengineering the heart: Conductive scaffolds enhance connexin 43 expression,” Jin-Oh You, Marjan Rafat, George J. C. Ye, and Debra T. Auguste, Nano Letters, 2011, 11(9) 3643-3648.
“Bioresponsive matrices in drug delivery,” Jin-Oh You, Dariela Almeda, George J. C. Ye, and Debra T. Auguste, Journal of Biological Engineering, 2010, 4(15) 1-12.
“The effect of swelling and cationic character on gene transfection by pH-sensitive nanocarriers,” Jin-Oh You and Debra T. Auguste, Biomaterials, 2010, 31(26) 6859-6866.
“Conductive, physiologically responsive hydrogels,” Jin-Oh You and Debra T. Auguste, Langmuir, 2010, 26(7) 4607-4612.
“Nanocarrier cross-linking density and pH sensitivity regulate intracellular gene transfer,” Jin-Oh You and Debra T. Auguste, Nano Letters, 2009, 9(12) 4467-4473.
“Feedback-regulated paclitaxel delivery based on poly(N,N-dimethylaminoethyl methacrylate-co-2-hydroxyethyl methacrylate) nanoparticles,” Jin-Oh You and Debra T. Auguste, Biomaterials, 2008, 29(12) 1950-1957.
PARTNERSHIP
We explore partnerships
to broaden and accelerate development and commercialization of our
(bilico and our partners) technology.
For partnership inquiries, please contact cs@bilico.com